Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms of SCN2A epilepsy.

SCN2A, encoding the voltage-gated sodium channel Nav1.2, has emerged as a major gene implicated in neonatal-, infantile-, and even childhood-onset epilepsies. Many of these epilepsies are also associated with cognitive and behavioral impairments that range in type and severity.

 

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**The leading authors on this paper are Florey scientists, many working directly under Steve Petrou

Proceedings of the National Academy of Sciences 115.24 (2018): E5516-E5525.
Berecki, G├ęza, et al.
http://www.pnas.org/content/115/24/E5516.short